Ethyl 5-(4-hydroxyphenyl)-1,3-oxazole-4-carboxylate
ethyl 5-(4-hydroxyphenyl)oxazole-4-carboxylate
CAS: 391248-24-1
Molecular Formula: C12H11NO4
Ethyl 5-(4-hydroxyphenyl)-1,3-oxazole-4-carboxylate - Names and Identifiers
| Name | ethyl 5-(4-hydroxyphenyl)oxazole-4-carboxylate |
| Synonyms | LogP ethyl 5-(4-hydroxyphenyl)oxazole-4-carboxylate Ethyl 5-(4-hydroxyphenyl)-1,3-oxazole-4-carboxylate 5-(4-hydroxyphenyl)-4-oxazolecarboxylic acid ethyl ester 4-Oxazolecarboxylic acid, 5-(4-hydroxyphenyl)-, ethyl ester |
| CAS | 391248-24-1 |
| InChI | InChI=1/C12H11NO4/c1-2-16-12(15)10-11(17-7-13-10)8-3-5-9(14)6-4-8/h3-7,14H,2H2,1H3 |
Ethyl 5-(4-hydroxyphenyl)-1,3-oxazole-4-carboxylate - Physico-chemical Properties
| Molecular Formula | C12H11NO4 |
| Molar Mass | 233.22 |
| Density | 1.27g/cm3 |
| Boling Point | 410.2°C at 760 mmHg |
| Flash Point | 201.9°C |
| Vapor Presure | 2.59E-07mmHg at 25°C |
| Refractive Index | 1.561 |
Ethyl 5-(4-hydroxyphenyl)-1,3-oxazole-4-carboxylate - Introduction
Ethyl 5-(4-hydroxyphenyl)oxazole-4-carboxylate is an organic compound with the chemical formula C14H11NO3. The following is a detailed description of its nature, use, preparation and safety information:
Nature:
1. Appearance: ethyl 5-(4-hydroxyphenyl)oxazole-4-carboxylate is white crystal or crystalline powder.
2. melting point: about 122-124 degrees Celsius.
3. Solubility: It is soluble in common organic solvents.
Use:
1. drug: ethyl 5-(4-hydroxyphenyl)oxazole-4-carboxylate is one of the intermediates of synthetic drugs, which can be used to synthesize benzofuran compounds and steroid compounds.
2. Chemical research: It can also be used as a derivative in organic synthesis for reaction substrates or catalysts.
Preparation Method:
ethyl 5-(4-hydroxyphenyl)oxazole-4-carboxylate can be prepared by the following methods:
Through the synthesis reaction of benzofuran, ethyl formate is reacted with aniline to produce an aniline compound. This compound is then reacted with 2-bromoacetone to give ethyl 5-(4-hydroxyphenyl)oxazole-4-carboxylate.
Safety Information:
The specific toxicological properties and safety information regarding the ethyl 5-(4-hydroxyphenyl)oxazole-4-carboxylate need to be evaluated in greater detail. When using this compound, appropriate laboratory safety practices should be followed, and waste should be properly stored, handled and disposed of in accordance with the information provided in the Material Safety Data Sheet (MSDS). A safety assessment and appropriate protective measures are always recommended before any chemical experiments are carried out.
Nature:
1. Appearance: ethyl 5-(4-hydroxyphenyl)oxazole-4-carboxylate is white crystal or crystalline powder.
2. melting point: about 122-124 degrees Celsius.
3. Solubility: It is soluble in common organic solvents.
Use:
1. drug: ethyl 5-(4-hydroxyphenyl)oxazole-4-carboxylate is one of the intermediates of synthetic drugs, which can be used to synthesize benzofuran compounds and steroid compounds.
2. Chemical research: It can also be used as a derivative in organic synthesis for reaction substrates or catalysts.
Preparation Method:
ethyl 5-(4-hydroxyphenyl)oxazole-4-carboxylate can be prepared by the following methods:
Through the synthesis reaction of benzofuran, ethyl formate is reacted with aniline to produce an aniline compound. This compound is then reacted with 2-bromoacetone to give ethyl 5-(4-hydroxyphenyl)oxazole-4-carboxylate.
Safety Information:
The specific toxicological properties and safety information regarding the ethyl 5-(4-hydroxyphenyl)oxazole-4-carboxylate need to be evaluated in greater detail. When using this compound, appropriate laboratory safety practices should be followed, and waste should be properly stored, handled and disposed of in accordance with the information provided in the Material Safety Data Sheet (MSDS). A safety assessment and appropriate protective measures are always recommended before any chemical experiments are carried out.
Last Update：2024-04-09 21:54:55
